Global Prevalence of Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis with New Data from Rio de Janeiro, Brazil

Key Points

• To evaluate the global prevalence of neuromyelitis optica spectrum disorder and compare it with regional data from Brazil.
• Conducted a global systematic review on NMOSD prevalence
• Performed a regional population-based analysis in southeastern Brazil
• Executed a meta-analysis to synthesize global and local prevalence data
• Found that NMOSD prevalence in Brazil exceeds the global pooled estimate
• Confirmed higher prevalence rates in the Americas
• Observed a correlation between prevalence and African ancestral backgrounds

Abstract