Misdiagnosis of different types of aneuploidy in preimplantation genetic testing (PGT): a systematic review and meta-analysis

Key Points

• To assess the misdiagnosis rates of different types of aneuploidies, particularly segmental aneuploidies, in preimplantation genetic testing.
• Conducted a systematic review and meta-analysis of existing studies on PGT-A.
• Analyzed data on misdiagnosis rates associated with segmental aneuploidies versus other types.
• Evaluated the implications of trophectoderm biopsy results.
• Embryos with segmental aneuploidies show a significantly higher risk of being misdiagnosed.
• Caution is recommended when interpreting results from trophectoderm biopsy for segmental aneuploidies.
• Misinterpretations can lead to the discard of potentially viable embryos.

Abstract