Pd-Catalyzed Buchwald-Hartwig Coupling of Imidazo1,2-bpyridazine with Aryl/Hetero Aryl Amines for the Synthesis of Functionalized Pyridazines

Key Points

• The aim is to develop a practical method for synthesizing substituted aryl/heteroaryl aminopyridazines.
• Developed a Pd-catalyzed coupling method.
• Utilized chloropyridazines and aryl/heteroaryl amines.
• Tested a range of functional groups including heterocycles.
• Successfully synthesized a variety of secondary heterocyclic aminopyridazines.
• Method tolerated diverse functional groups, including electron-withdrawing and donating groups.
• Facilitated the creation of compounds that were challenging to obtain previously.

Abstract