Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study

Key Points

• To identify protein signatures that serve as biomarkers for predicting the risk of cardiometabolic diseases in individuals with preserved ratio impaired spirometry (PRISm).
• Conducted a longitudinal cohort study
• Analyzed plasma proteomic signatures
• Focused on individuals with PRISm
• Assessed the relationship between biomarkers and cardiometabolic complications
• Identified specific protein signatures linked to PRISm
• Demonstrated potential for early identification of high-risk individuals
• Indicated that these biomarkers could inform preventive strategies for cardiometabolic diseases

Abstract