Clinicopathological Spectrum of Gastrointestinal Stromal Tumours: A Case Series

Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal tract, accounting for less than 1% of all primary GIT tumors. In this small sized series, GISTs were identified in both the stomach and small intestine, highlighting the anatomical variability of these tumors. The primary objective of this case series was to characterize the clinicopathological features, histomorphology, immunohistochemical profile, and risk stratification of GISTs. Four patients diagnosed with GIST between January 2024 and December 2024 at a tertiary care hospital in Gujarat, India, were included in the study. The patients were adults aged 37–58 years. Spindle cell morphology was the predominant histological pattern observed, consistent with the typical morphology of GISTs. The novelty in this case series highlights the diagnostic utility of histomorphology and immunohistochemistry in resource-limited settings and underscores the importance of risk stratification in guiding management.