Olink Proteomics Reveals CCL2 Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High‐Altitude Migrants Via CCR2 / NF ‐ κB ‐Mediated Blood–Brain Barrier Disruption

Puntos clave

• The research aims to investigate how CCL2 contributes to secondary injury following intracerebral hemorrhage at high altitudes.
• Utilized Olink proteomics to analyze protein levels and pathways involved in edema
• Focused on the CCL2-CCR2-NF-κB signaling pathway
• Examined the role of CCL2 in inflammation and blood-brain barrier integrity
• CCL2 significantly amplifies inflammation following intracerebral hemorrhage
• Activation of the CCR2-NF-κB pathway leads to blood-brain barrier disruption
• CCL2 may serve as a potential therapeutic target to reduce secondary injury