Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inhibiting ferroptosis in chemotherapy-induced POF

Key Points

• The aim is to evaluate how isorhamnetin-preconditioned MSC-derived exosomes improve ovarian function and inhibit ferroptosis in a model of chemotherapy-induced POF.
• Comparison of isorhamnetin-preconditioned MSC-derived exosomes with conventional MSC-derived exosomes
• Assessment of ovarian function restoration
• Analysis of ferroptosis inhibition
• Proteomic analysis to identify key mechanistic pathways
• ISO-MSC-Exos demonstrated greater efficacy than MSC-Exos in restoring ovarian function
• Inhibition of ferroptosis was significantly enhanced with ISO pretreatment
• Proteomic data identified key pathways needing further validation

Abstract