Long-Term Durability and Dynamics of Anti-S-RBD IgG Response in Healthcare Workers: A Comparative Analysis of Homologous and Heterologous SARS-CoV-2 Vaccination Schedules in a 1-Year Serial Cross-Sectional Study

Key Points

• This research aims to investigate the long-term durability of the anti-S-RBD IgG response in healthcare workers vaccinated with homologous versus heterologous SARS-CoV-2 schedules.
• Conducted a 1-year serial cross-sectional study.
• Analyzed IgG response in healthcare workers.
• Compared responses between homologous and heterologous vaccination schedules.
• Anti-S-RBD IgG levels showed varying durability between homologous and heterologous groups.
• Heterologous vaccination resulted in a stronger and longer-lasting IgG response over the study period.

Abstract