ZhiXiaoSanZheng formula ameliorates podocyte injury in diabetic kidney disease by inhibiting ferroptosis: integrated network pharmacology and experimental validation

Key Points

• The study aims to investigate how ZhiXiaoSanZheng formula impacts podocyte injury in diabetic kidney disease through ferroptosis modulation.
• Utilized network pharmacology to identify key pathways involved.
• Conducted experimental validation to assess the effects of ZXSZF.
• Focused on the NRF2/SLC7A11/GPX4 pathway related to ferroptosis.
• ZXSZF significantly alleviated podocyte injury in diabetic kidney disease.
• The renoprotective effects were linked to modulation of ferroptosis-related pathways.
• Supportive evidence highlighted the NRF2/SLC7A11/GPX4 pathway's role in the process.

Abstract