Integrative multi‐omics suggests core gene dysregulation of histidine metabolism in diabetic kidney disease

Key Points

• This research explores the dysregulation of histidine metabolism in diabetic kidney disease through multi-omics approaches.
• Conducted multi-omics analyses to assess metabolomic and genomic data.
• Integrated various omics data to identify dysregulation pathways.
• Focused on histidine metabolism and its implications in diabetic kidney disease.
• Histidine metabolism shows significant dysregulation in diabetic kidney disease.
• Identified key genes involved in histidine metabolism that may represent potential therapeutic targets.
• Proposed novel mechanistic insights related to pathological events in diabetic kidney disease.

Abstract