What question did this study set out to answer?

Assess the impact of STAT3 and STAT5 mutations on overall survival in plasma cell myeloma patients.

April 10, 2026

STAT3 / STAT5 Mutations Predict Shorter Overall Survival in Patients with Plasma Cell Myeloma

Key Points

Assess the impact of STAT3 and STAT5 mutations on overall survival in plasma cell myeloma patients.
Analyzed patient data for STAT3/STAT5 mutations
Evaluated clinical features associated with these mutations
Assessed overall survival rates among patients with mutations
STAT3/STAT5 mutations are prevalent in plasma cell myeloma
Patients with these mutations experience shorter overall survival
Mutations correlate with adverse clinical features

Abstract

STAT3/STAT5 mutations are early, dominant, and potentially pathogenic events in plasma cell myeloma. Their association with adverse clinical features and inferior survival supports their routine assessment and potential therapeutic targeting.

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Discussion

Authors

Matthew T. Ye

Zhuang Zuo

Steliana Calin

Journals

European Journal Of Haematology

Actions

Institutions

The University of Texas MD Anderson Cancer Center

Vanderbilt University

City Of Hope National Medical Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

STAT3 / STAT5 Mutations Predict Shorter Overall Survival in Patients with Plasma Cell Myeloma

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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