Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In Vitro Evidence

Key Points

• This research aims to explore the role of chemerin in fetal endothelial dysfunction linked to gestational diabetes mellitus (GDM).
• Analyzed circulating chemerin levels in pregnancies with GDM.
• Studied mRNA and protein expression to assess post-transcriptional regulation.
• Investigated the utility of cord blood chemerin as a biomarker for vascular injury.
• Evaluated fetal arterial pulse velocity (APV) as a non-invasive assessment tool.
• Found elevated levels of chemerin in GDM patients associated with endothelial dysfunction.
• Observed discordance between mRNA and protein levels indicating complex regulatory mechanisms.
• Identified cord blood chemerin as a potential biomarker for assessing fetal vascular injury.
• Highlighted the need for studies on CMKLR1 antagonists to explore therapeutic options.

Abstract