Hypoxia-Induced Ferroptosis Resistance Drives Orbital Fibrosis in Thyroid Eye Disease

Key Points

• The research aims to explore how hypoxia contributes to ferroptosis resistance and promotes fibrosis in thyroid eye disease orbital fibroblasts.
• Analyzed lactate accumulation in hypoxic conditions
• Investigated GPX4 involvement in ferroptosis resistance
• Assessed fibrotic activation markers in orbital fibroblasts
• Proposed metabolic inhibition combined with ferroptosis induction for treatment
• Hypoxia leads to increased lactate levels in orbital fibroblasts
• Findings suggest GPX4 is linked to resistance to ferroptosis
• Profibrotic activation is amplified under hypoxic conditions
• Metabolic inhibition and ferroptosis induction show potential as a therapeutic strategy

Abstract