Herein, two bifunctional glucose dehydrogenases (GDHs) are reported that can efficiently catalyze the ketone reduction of α-ketoalkynes while regenerating NADPH for the ketone reduction process. The GDH-catalysed reaction can accept multiple types of α-ketoalkynes, including one particularly bulky substrate that typical alcohol dehydrogenases (ADHs) cannot efficiently work on. Notably, the developed biocatalytic approach allows gram-scale synthesis and the access to both (R) and (S) enantiomers of the products.
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Kumar et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d895796c1944d70ce06710 — DOI: https://doi.org/10.1039/d5cc07322g
Rohit Kumar
Simran Bhatia
Samantha J. Tambrini
Chemical Communications
Wayne State University
Eugene Applebaum College of Pharmacy and Health Sciences
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