Asymmetric synthesis of propargylic alcohols using bifunctional glucose dehydrogenases

Key Points

• The aim is to explore the use of bifunctional glucose dehydrogenases to synthesize propargylic alcohols through ketone reduction.
• Characterization of bifunctional glucose dehydrogenases (GDHs)
• Evaluation of GDH-catalyzed reactions on multiple α-ketoalkynes
• Synthesis of both (R) and (S) enantiomers at gram-scale
• GDHs efficiently catalyze the ketone reduction of α-ketoalkynes
• Demonstrated ability to work with bulky substrates that typical alcohol dehydrogenases cannot process
• Successful production of both (R) and (S) enantiomers in significant quantities

Abstract