Prognostic significance of soluble urokinase-type plasminogen activator receptor in patients with glomerulonephritis: association with renal outcomes

Key Points

• The aim is to determine the prognostic role of soluble urokinase-type plasminogen activator receptor (suPAR) in predicting renal outcomes in glomerulonephritis patients.
• Analyzed biopsy-proven primary glomerulonephritis cases.
• Measured levels of soluble urokinase-type plasminogen activator receptor at biopsy.
• Assessed the association between suPAR levels and renal function decline.
• Higher suPAR levels at biopsy predicted a decline in estimated glomerular filtration rate (eGFR).
• suPAR levels were not associated with changes in proteinuria over time.

Abstract