OncoRisk: a state-of-the-art web server for bridging the oncogenic databases and pan-cancer cohorts to the translational oncology

Abstract Accurate interpretation of genomic variants remains a major bottleneck in precision oncology, due in part to fragmented knowledge across databases and limited integration between clinical evidence and population-scale genomic datasets. Here we present OncoRisk, a stand-alone, user-friendly web server that unifies data from over ten oncogenic databases and seven large-scale pan-cancer cohorts, enabling rapid multi-database queries and network-based exploration of genomic variants, gene-gene interactions, and therapy associations. The platform features a semi-automated reporting workflow that generates comprehensive, patient-specific clinical reports from raw tissue sequencing data and categorizes variants into actionable tiers. For translational research, OncoRisk provides modules for data-driven exploration, allowing users to validate findings by interrogating mutation frequencies and clinical associations across real-world patient data. Furthermore, an integrated suite of analytical tools enables comprehensive, cohort-level investigations of mutational landscapes, prognostic biomarkers, and oncogenic signaling pathways. By providing a unified ecosystem that bridges curated knowledge with large-scale cohort data, OncoRisk serves as an effective catalyst for both discovery research and clinical application in oncology. OncoRisk is publicly available at https://www.phenomeportal.org/oncorisk .