Association of Human Leucocyte Antigen with Tacrolimus Pharmacokinetics in Renal Transplant Patients

Key Points

• The study aims to investigate how HLA alleles impact tacrolimus pharmacokinetics and graft survival in renal transplant recipients.
• Analyzed the relationship between HLA alleles and tacrolimus pharmacokinetics.
• Evaluated graft survival rates in relation to HLA alleles.
• Utilized pharmacokinetic modeling to assess tacrolimus levels.
• HLA alleles significantly influenced tacrolimus pharmacokinetics.
• Patients with specific HLA alleles had better graft survival rates.

Abstract