Association of PTPN22 and NLRP3 Gene Polymorphisms with Psoriasis Susceptibility in a Han Chinese Population

Key Points

• To explore the connection between PTPN22 and NLRP3 gene polymorphisms and the risk of developing psoriasis.
• Genetic analysis of the PTPN22 rs2488457 locus
• Examination of allele distribution in the Jiujiang population
• Comparison of genotypes among individuals with psoriasis and healthy controls
• The GG genotype and G allele of PTPN22 rs2488457 may increase susceptibility to psoriasis
• Statistical significance was observed in the association between the GG genotype and psoriasis risk.

Abstract