Gene–Environment Interactions for Alzheimer's Disease Pathology in Cognitively Normal Adults: The CABLE Study

Key Points

• This research aims to explore how genetic and environmental factors interact to influence Alzheimer's disease pathology in cognitively normal adults.
• Analyzed associations between genetic risk (AD-PRS) and amyloidosis severity.
• Examined the impact of modified risk factors such as anemia, gingivitis, and anxiety on biomarker ratios.
• Investigated the relationship between healthy lifestyle choices and amyloid burden across different genetic risk groups.
• AD-PRS showed a significant correlation with the severity of amyloidosis.
• Modified risk factors affected biomarker ratios differently based on genetic risk levels.
• Individuals with high genetic risk who maintained a healthy lifestyle exhibited a reduced amyloid burden.

Abstract