Forsythoside A Alleviates Neuroinflammatory Damage via Inhibiting TLR4 / NF ‐ κB / NLRP3 Activation‐Induced Astrocyte Pyroptosis in Cerebral Ischemia–Reperfusion

Key Points

• The study aims to investigate the effects of Forsythoside A on neuroinflammatory damage during cerebral ischemia–reperfusion.
• Utilized animal models of cerebral ischemia–reperfusion.
• Administered Forsythoside A to assess its neuroprotective effects.
• Analyzed TLR4/NF-κB/NLRP3 pathways in astrocytes.
• Forsythoside A significantly inhibits TLR4 and NF-κB activation.
• Reduces NLRP3 inflammasome activation leading to decreased astrocyte pyroptosis.
• Demonstrated reduced neuroinflammatory damage in treated models.

Abstract