Volumising, biostimulative and uniquely regenerative: a review of calcium hydroxylapatite

Calcium hydroxylapatite (CaHa) has emerged as a versatile agent in regenerative aesthetics, offering volumising, biostimulatory, and tissue-regenerative effects. Unlike traditional fillers that primarily replace volume, CaHa restores extracellular matrix integrity by stimulating collagen, elastin, and proteoglycan production through mechanotransduction, promoting youthful tissue architecture without provoking significant inflammation. Suspended in carboxymethylcellulose, CaHa demonstrates excellent safety, biocompatibility, and biodegradability, while its rheological properties allow precise sculpting and lifting. Evidence highlights enhanced fibroblast function, neocollagenesis, angiogenesis, and improved skin quality, positioning CaHa as a model regenerative filler that simultaneously provides immediate volumetric support and long-term dermal restoration.