Біокаталітичний підхід до синтезу альдегідів з використанням ліофілізатів гриба Bjerkandera adusta

An optimized biocatalytic oxidation protocol has been developed for the efficient conversion of benzylic and allylic alcohols into their corresponding aldehydes. The sustainable method uses lyophilized mycelia of Bjerkandera adusta white-rot fungus as a catalyst in the aqueous medium with 2-propanol (10% v/v) as a co-solvent, and operates under mild conditions to give high yields for a wide range of substrates. On a preparative scale, the approach allowed the synthesis of important aldehydes, including benzaldehyde, piperonal, cinnamaldehyde, cuminaldehyde, methoxybenzaldehydes, and citral.