Photocatalytic anti-Markovnikov Chloroalkynylation of Unactivated Alkenes

Key Points

• This research aims to develop a photocatalytic method for effectively producing chloroalkynes from unactivated alkenes.
• Utilized a neutral acridine photocatalyst to enable cascade radical reactions.
• Employs proton-coupled electron transfer using HCl and alkynyl sulfones.
• Explored the reaction with various unactivated alkenes, including diverse derivatives.
• Successfully produced highly regioselective chloroalkyne products from unactivated alkenes.
• Showed compatibility with alkyl-substituted and drug-like alkenes.
• Demonstrated the synthetic utility of chloroalkyne building blocks for further derivatization.

Abstract