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This research investigates how SCFA receptors contribute to macrophage polarization in periodontitis.

April 10, 2026Open Access

Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro‐Inflammatory M1 Macrophage Polarization in Periodontitis

Key Points

This research investigates how SCFA receptors contribute to macrophage polarization in periodontitis.
Examined SCFA receptor expression in macrophages.
Analyzed the NF-κB/HIF-1 signaling pathway.
Studied metabolic changes associated with periodontitis.
Found increased expression of SCFA receptors in M1 macrophages.
Identified a significant upregulation of NF-κB and HIF-1 in pro-inflammatory macrophages.
Proposed a mechanism by which SCFA receptors drive inflammation in periodontitis.

Abstract

Periodontitis is characterized by SCFA metabolic imbalance and a shift in MCs toward a pro-inflammatory M1 state. The upregulation of SCFA receptors and the NF-κB/HIF-1 axis in M1 macrophages suggests an "SCFA receptor-metabolic sensing-inflammatory transcription" mechanism drives disease progression, providing a rationale for therapeutic strategies targeting this pathway.

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Discussion

Authors

Kun Liu

Ruolin Wang

Lingxue Kong

Journals

Mediators of Inflammation

Actions

Institutions

Jinan Stomatological Hospital

Tissue Regeneration Systems (United States)

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Building similarity graph...

Analyzing shared references across papers

Signaling Through SCFA Receptors Gpr43 and Gpr109a Drives Pro‐Inflammatory M1 Macrophage Polarization in Periodontitis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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