Are pathway-specific polygenic risk scores associated with cardiorenal complications in Asians with Type 2 diabetes?
Multi-ethnic Asian population with Type 2 Diabetes
Pathway-specific polygenic risk scores
Cardiorenal outcomes and related circulating proteins
Pathway-specific polygenic risk scores show differential associations with cardiorenal outcomes in Asian patients with type 2 diabetes, highlighting the potential relevance of biologically informed genetic pathways.
In a multi-ethnic Asian population, pathway-specific genetic susceptibility was differentially associated with cardiorenal outcomes and related circulating proteins. These findings suggest the potential relevance of biologically informed genetic pathways in diverse populations and warrant validation in independent cohorts.
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Resham L Gurung
Huili Zheng
Jia Le Ivan Tan
Diabetes Obesity and Metabolism
National University of Singapore
Nanyang Technological University
National University Health System
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Gurung et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d896676c1944d70ce07cb2 — DOI: https://doi.org/10.1111/dom.70741