NECTIN4 amplification is a frequent event in central nervous system metastases of urothelial carcinoma

Key Points

• To investigate the role of NECTIN4 amplification as a biomarker in metastatic urothelial carcinoma.
• Analysis of NECTIN4 amplification in central nervous system metastases.
• Evaluation of its predictive value for targeted anti-NECTIN4 therapies.
• Comparison with other cancers like triple-negative breast cancer and non-small cell lung cancer.
• NECTIN4 amplification was frequently observed in CNS metastases of urothelial carcinoma.
• Identification of NECTIN4 as a potential predictor of therapy response.
• Amplification presence suggests therapeutic targeting possibilities.

Abstract