NR3C1 activation of IRGM1 alleviates early brain injury after subarachnoid hemorrhage by inhibiting inflammation, pyroptosis, and oxidative stress.
Does targeting the NR3C1/IRGM1 axis alleviate early brain injury after subarachnoid hemorrhage?
Models of early brain injury after subarachnoid hemorrhage (SAH)
Targeting the NR3C1/IRGM1 axis (NR3C1 transcriptional activation of IRGM1)
Inflammation, pyroptosis, oxidative stress, and early brain injury (EBI)surrogate
Activation of the NR3C1/IRGM1 axis reduces inflammation and pyroptosis, offering a potential therapeutic target for early brain injury following subarachnoid hemorrhage.
NR3C1 transcriptionally activated IRGM1 to inhibit inflammation, pyroptosis, and oxidative stress, thereby alleviating EBI after SAH, and targeting the NR3C1/IRGM1 axis might provide a novel therapeutic strategy for SAH.
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Yuanjun Xin
Min Gong
Xiaohong Fu
Shock
First People’s Hospital of Zunyi
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Xin et al. (Fri,) reported a other. NR3C1 activation of IRGM1 alleviates early brain injury after subarachnoid hemorrhage by inhibiting inflammation, pyroptosis, and oxidative stress.
www.synapsesocial.com/papers/69d896676c1944d70ce07e01 — DOI: https://doi.org/10.1097/shk.0000000000002846