Hormone Therapy After Oophorectomy and Breast Cancer Risk in Women With BRCA Pathogenic Variant

Key Points

• This research aims to evaluate the breast cancer risk associated with hormone therapy in women with BRCA pathogenic variants after oophorectomy.
• Cohort study design
• Participants included women with BRCA pathogenic variants
• Comparison of estrogen-only and combined hormone therapy outcomes
• Estrogen-only hormone therapy did not increase breast cancer risk
• Lower risk of breast cancer observed in women with BRCA1 pathogenic variants receiving estrogen-only therapy
• Combined estrogen-progestin therapy showed no significant risk modification

Abstract