EZH2‐Mediated Epigenetic Modifications Induce Pyroptosis in Dental Pulp Endothelial Cells via Activation of NLRP6 Inflammasome During Pulpitis Development

Key Points

• The research aims to understand how EZH2 regulates pyroptosis in endothelial cells during pulpitis by activating the NLRP6 inflammasome.
• Investigated the role of EZH2 in endothelial cells during pulpitis development
• Analyzed NLRP6 inflammasome activation
• Assessed pyroptosis as a form of programmed cell death
• EZH2 was identified as a key regulator in inflammation of endothelial cells during pulpitis.
• Activation of the NLRP6 inflammasome by EZH2 led to pyroptosis in these cells.

Abstract