ROS-accelerated quinone formation from gossypol in a dendritic AIE polymer enables synergistic type I photodynamic therapy and chemotherapy

Key Points

• The research aims to develop a polymer-based delivery system for gossypol to improve photodynamic therapy and chemotherapy outcomes.
• Synthesis of TPAGH polymer as a photosensitizer for gossypol delivery
• Creation of TPAGH-GS with pH-responsive release features
• Evaluation of phototherapy enhancement through quinone-mediated reactions
• Demonstrated improved delivery and release of gossypol using TPAGH-GS
• Achieved enhanced phototherapeutic effects through quinone formation
• Showed synergistic effects when combining photodynamic therapy with traditional chemotherapy

Abstract