Distinct inflammatory programming of thoracic cavity white adipose immune cells regulates influenza pathogenesis

Key Points

• The research aims to explore how thoracic cavity white adipose tissue (tcWAT) influences immune responses during influenza A virus (IAV) infection.
• Identified lung-proximal tcWAT as a distinct tissue type.
• Analyzed immune cell characteristics within tcWAT during IAV infection.
• Examined the role of tcWAT in amplifying pathogenic immune responses.
• tcWAT exhibits unique inflammatory profiles compared to other tissues.
• Heightened immune responses in tcWAT correlate with worsened influenza pathogenesis.

Abstract