Concentration-Dependent Nucleation of Pyrazinamide Polymorphs Monitored by Dynamic Light Scattering

Key Points

• The aim is to understand how drug concentration affects the nucleation of pyrazinamide crystal forms.
• Utilized dynamic light scattering to assess the nucleation process.
• Examined various concentrations of pyrazinamide in solution.
• Monitored polymorphic transitions over time to identify nucleation points.
• Identified concentration-dependent behaviors in crystal formation.
• Observed distinct nucleation rates for different polymorphs of pyrazinamide.
• Demonstrated that higher concentrations can lead to increased nucleation speed.

Abstract