Chimeric Antigen Receptor Therapy

Key Points

• The review aims to explore the use of chimeric antigen receptor therapy in achieving long-term remissions in difficult-to-treat tumors.
• Conducted an interview with Dr. Carl June to gather expert insights.
• Reviewed literature on T-cell engineering and synthetic immunity.
• Summarized toxic effects associated with chimeric antigen receptor therapies.
• Chimeric antigen receptor therapy can produce durable remissions in refractory tumors.
• The therapy is associated with toxic effects, including cytokine release syndrome and neurologic dysfunction.