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August 11, 2024British Journal of Pharmacology143 citationsOpen Access

Natural product pharmacology: the British Journal of Pharmacology perspective

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XWXin WangAIAngelo A. IzzoAPAndreas Papapetropoulos

Key Points

  • Summarize reporting standards from the 2020 British Journal of Pharmacology guide and examine emerging methodologies to advance natural product drug discovery.
  • Reviewed natural product pharmacology papers published in the British Journal of Pharmacology from 2020 to 2023 for compliance with established reporting standards.
  • Evaluated the application of chemical proteomics technologies for elucidating natural product mechanisms of action and identifying drug targets.
  • Highlighted exemplar natural product pharmacology studies demonstrating adherence to rigorous experimental and reporting guidelines.
  • Identified chemical proteomics as a key innovative platform to pinpoint molecular targets and map mechanisms of action for complex bioactive compounds.

Abstract

Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In this editorial review, we highlight key points from the 2020 British Journal of Pharmacology (BJP) practical guide, which outlines standards for natural products research reports, and provide papers published in BJP between years 2020 to 2023 that demonstrate adherence to these guidelines. Looking ahead, we discuss the potential of chemical proteomics approaches to elucidate natural products mechanisms of action and identify therapeutic targets for future research. By fostering innovation, we aim to advance natural products research and contribute to the development of novel therapeutics that will have a significant impact on healthcare.

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Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/69d942eeccb0bba5a56847e8https://doi.org/10.1111/bph.17300
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