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April 11, 2026Journal of Applied Toxicology

Genotoxic and Biochemical Responses of the Amphibian Rhinella arenarum Under Exposure to the Herbicide 2,4‐Dichlorophenoxyacetic Acid (2,4‐D)

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Authors

MLMilagros R.R. LabordeCACeleste Ruiz de ArcauteSSSonia Soloneski

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Overview

Evaluates genotoxic and oxidative effects of herbicide exposure in amphibians, suggesting significant environmental implications.

Key Points

  • The aim is to assess the genotoxic and oxidative effects of 2,4-D on Rhinella arenarum tadpoles.
  • Acute exposure of tadpoles to 5 μg/L of 2,4-D under laboratory conditions.
  • Genotoxicity assessed using the alkaline comet assay for DNA breaks.
  • Oxidative stress evaluated by measuring catalase and GST activities and reduced glutathione levels.
  • Significant increases in DNA damage were observed, with 3.32- and 2.92-fold increases at 48 and 96 hours, respectively.
  • Catalase activity decreased by 43.8% after 96 hours of exposure.
  • Reduced glutathione levels decreased by 29.8%, indicating oxidative stress induction.

Cite This Study

Laborde et al. (2026) studied this question.

synapsesocial.com/papers/69d9e58f78050d08c1b75ceahttps://doi.org/10.1002/jat.70194
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