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April 11, 2026Chinese Science Bulletin (Chinese Version)0 citationsOpen Access

Hydrogen-Bonded Organic Frameworks for Photodynamic Antimicrobial Applications

SLShanshan LiWFWeiwei FengSJShuai Jiao

Key Points

  • The research aims to explore the potential of hydrogen-bonded organic frameworks in photodynamic antimicrobial applications.
  • Reviewed strategies for enhancing the stability of hydrogen-bonded organic frameworks.
  • Discussed photodynamic antibacterial mechanisms and recent advances in material design.
  • Analyzed the challenges and future directions regarding long-term stability and photosensitization.
  • Identified four main strategies for improving stability: π-π stacking, interpenetrating networks, chemical crosslinking, and charge assistance.
  • Outlined advancements in antibacterial mechanisms and complex environmental applications.
  • Highlighted the need for multifunctional platforms and intelligent design to address existing challenges in clinical use.

Abstract

氢键有机框架(hydrogen-bonded organic frameworks, HOFs)是一类由有机分子通过氢键等弱相互作用自组装形成的晶态多孔材料, 因其合成条件温和、生物相容性优良、结构可调、易于加工且可功能化等优点, 在多个领域展现出巨大应用潜力, 尤其在光动力抗菌领域. 本文系统梳理了提升HOFs稳定性的四大策略, 包括π-π堆积、互穿网络、化学交联和电荷辅助. 其次, 重点综述了HOFs在光动力抗菌领域中的最新研究进展, 涵盖抗菌机理、材料的设计与优化、复杂环境中的应用以及材料体系创新等方面. 最后, 针对HOFs在生理环境长期稳定性不足、光敏性能有待提升等现存挑战, 对其在光动力抗菌方面的发展前景进行了展望, 提出应聚焦于多功能协同平台搭建、材料智能设计及跨领域应用场景拓展, 以推动HOFs向临床及实用化方向发展.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69d9e5ec78050d08c1b76288https://doi.org/10.1360/csb-2025-5974
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