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April 11, 2026BiologyOpen Access

Sorghum Promotes Cell Proliferation Through Activation of the Growth Hormone/IGF-1–JAK2/STAT5b Signaling Axis In Vitro

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Authors

SPSanghyeon ParkDKDong Young KangHKHyo Kim

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Overview

In vitro experiments show sorghum enhances cell proliferation via JAK2/STAT5b and IGF-1 pathways, indicating potential health benefits.

Key Points

  • To explore how sorghum extract impacts cell growth and identifies the underlying molecular mechanisms.
  • Evaluated cytotoxicity of sorghum extract in murine myoblasts and fibroblasts.
  • Assessed DNA damage to determine the safety of sorghum extract.
  • Monitored activation of JAK2/STAT5b and IGF-1 pathways.
  • Studied transcriptional regulation by examining STAT5b/DNA binding and promoter activity.
  • Sorghum extract increased cell proliferation in C2C12 and C3H10T1/2 cells.
  • Observed activation of JAK2/STAT5b and IGF-1 pathways in treated cells.
  • Enhanced STAT5b binding led to increased IGF-1 expression.
  • Upregulation of growth hormone receptor and bone morphogenetic protein 7 was noted.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69d9e5ec78050d08c1b76340https://doi.org/10.3390/biology15080594
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