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April 11, 2026Organic Letters2 citations

A 6/5/6/5-Fused Indeno7,1- bc furan Diterpenoid Skeleton from Pinus yunnanensis Resins with Anti-Neuroinflammatory and Antidepressant Activities

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JLJing LiuWLWenhua LiSLShao-Jin Luo

Key Points

  • This research aims to isolate and characterize a novel diterpenoid and evaluate its effects on neuroinflammation and depressive behavior.
  • Isolated Pinynditerpene A from Pinus yunnanensis resins
  • Elucidated structure using spectroscopic, computational, and crystallographic methods
  • Assessed anti-neuroinflammatory and antidepressant activities in mice
  • Pinynditerpene A has a unique 6/5/6/5-fused indeno[7,1-bc]furan skeleton
  • Demonstrated ability to alleviate inflammation linked to depression-like behaviors in mice

Abstract

Pinynditerpene A (1), an unprecedented abietane diterpenoid featuring a unique 6/5/6/5-fused indeno7,1-bcfuran skeleton with 5 consecutive chiral centers, was isolated from Pinus yunnanensis resins. Its structure was elucidated by spectroscopic, computational, and crystallographic methods. 1 was found to be able to alleviate inflammation associated depression-like behaviors in mice, exerting its significance in mood disorders.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69d9e64e78050d08c1b76a1ehttps://doi.org/10.1021/acs.orglett.6c00841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discovery of Terpenoidal Trimers Gercadietanes A–G from <i>Commiphora</i> Resins Showing Potential Antidepressant Properties In Vivo2026
  2. 2Dfpenicimeroterpenoid A, Meroterpenoids with 6/6/6/4/5 Polycyclic Skeletons from the Marine-Derived Fungus <i>Penicillium</i> sp. DF712026 · 1 citations
  3. 3Chemical constituents and anti-renal fibrosis activity of the resin from Pinus yunnanensis.2026
  4. 4Abietane-Type Diterpenoids from the Resin of Pinus yunnanensis and Their Potential Anti-Renal Fibrosis Activities2026
  5. 5Peniditerpenoids A and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove-Sediment-Derived <i>Penicillium</i> sp.2024 · 10 citations