What question did this study set out to answer?

This analysis aims to explore the relationship between neurovascular unit dysfunction and cerebral small vessel disease in Parkinson Disease.

April 12, 2026Neurology0 citations

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Neurovascular Unit Dysfunction and Cerebral Small Vessel Disease in Parkinson Disease

DPDylan Del PapaJohns Hopkins University JHJessica HermanUniversity of Miami AKAidan Theepura KunjuUniversity of Miami

Key Points

This analysis aims to explore the relationship between neurovascular unit dysfunction and cerebral small vessel disease in Parkinson Disease.
Analyzed the association between Parkinson Disease and white matter hyperintensities (WMH).
Examined midbrain enlarge perivascular spaces (ePVS) in relation to Parkinson Disease.
Assessed pooled differences in cerebral microbleeds (CMB) and lacunes.
Parkinson Disease showed a greater burden of WMH.
Increased midbrain ePVS was associated with Parkinson Disease.
No significant pooled differences in CMB and lacunes were found.

Abstract

Our analysis showed PD to be associated with greater WMH burden and increased midbrain ePVS. Pooled differences in CMB and lacunes were not significant. Substantial heterogeneity and cross-sectional designs limit certainty; standardized imaging and prospective cohorts are needed to define mechanisms and clinical implications.

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Neurovascular Unit Dysfunction and Cerebral Small Vessel Disease in Parkinson Disease

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