Plasma 1H NMR-based metabolomic analysis reveals the lipid regulating effect of novel carboxamide derivatives in hyperlipidemic rats

Key Points

• This research aims to evaluate the lipid-regulating effects of novel carboxamide derivatives in a hyperlipidemic model.
• Plasma 1H NMR-based metabolomic analysis was conducted.
• Hyperlipidemic rats were treated with carboxamide derivatives.
• Lipid profiles and metabolic alterations were measured and compared to conventional drugs.
• Both carboxamide derivatives demonstrated significant lipid-lowering activity.
• Compound A significantly reduced triglycerides levels.
• The effects were comparable to fenofibrate, a standard lipid-lowering drug.

Abstract