Anticancer and Apoptotic Effect of Alogliptin on A549 Cancer Cell Line

Key Points

• The aim is to investigate the anticancer effects of alogliptin on A549 cancer cells.
• Measured DPP-4 inhibition
• Assessed apoptotic pathway activation
• Evaluated oxidative stress levels
• Analyzed biomarkers including BAX, caspase-3, and MDA
• Alogliptin significantly induced cancer cell death
• DPP-4 inhibition correlated with enhanced oxidative stress
• Apoptotic markers BAX and caspase-3 showed increased expression

Abstract