We herein report a copper-mediated, visible-light-promoted cross-coupling of aryl thianthrenium salts with (DMPU)2Zn(Rf)2 reagents for site-selective late-stage perfluoroalkylation of arenes. The protocol displays a broad substrate scope and outstanding functional-group tolerance, accommodating diverse functional moieties, heterocyclic motifs, and complex drug-derived scaffolds. This approach markedly enriches the repertoire of late-stage perfluoroalkylation methods, providing a unified, modular, and chain-length-tunable platform for the construction of perfluoroalkylated compounds with potential applications in materials science, medicinal chemistry, and agrochemical development.
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Yun Yang
Lili Zhao
Shengsheng Luo
Chemical Communications
Nanchang University
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Yang et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69db36e64fe01fead37c4dc7 — DOI: https://doi.org/10.1039/d6cc01493c