Abstract Extramammary Paget’s disease (EMPD) is a rare form of malignancy affecting the skin of the genitals, perineum, or perianal region, which has clinical, histological, and immunohistochemical (IHC) features similar to Paget’s disease of the breast. The frequency of occurrence of this disease in the population has not been studied in detail. The clinical picture of the disease is nonspecific and requires differential diagnosis with inflammatory diseases of the genitals. The main method of diagnosis is histological and IHC analysis. Due to the rare occurrence of this disease, there is no standard form of its treatment. Surgical excision is the primary method of treatment for local lesions without metastases. Systemic chemotherapy (vincristine, docetaxel, carboplatin, 5-fluorouracil, mitomycin C, and etoposide) is applicable for the metastatic forms of EMPD. In this clinical report, we have discussed the clinical, dermatoscopic, histological, and IHC features of three male patients with the treatments and results of the provided treatment.
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Roman A. Ravodin
Angela Asedova
R. Ranjit
Journal of Dermatology & Dermatologic Surgery
Pirogov Russian National Research Medical University
Peoples' Friendship University of Russia
Ministry of Health
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Ravodin et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69db36e64fe01fead37c4e0a — DOI: https://doi.org/10.4103/jdds.jdds_9_25