Rational design, molecular characterization and dissociation mechanisms of PROTACs targeting hFAAH

Key Points

• The study aims to design and characterize PROTACs that inhibit FAAH to modulate the endocannabinoid system.
• Rational design of PROTACs targeting FAAH
• Molecular characterization of the PROTACs
• Assessment of FAAH inhibition and anandamide levels
• PROTACs effectively inhibit FAAH activity
• Inhibition leads to increased levels of anandamide
• Characterization reveals specific binding and dissociation mechanisms

Abstract