Role of Cannabinoid Receptor Type 2 in Acute Behavioral Responses to Graft Versus Host Disease in Male Mice

Key Points

• This research investigates the impact of cannabinoid receptor type 2 (CB2R) on behavior and neuronal health in male mice with graft versus host disease.
• Deletion of CB2R in recipient mice
• Assessment of neuronal loss
• Evaluation of behavioral responses during disease progression
• CB2R deletion protects against neuronal loss in the brain
• Deletion prevents inflammation in the brain
• Acute behavioral dysregulation persists despite CB2R deletion

Abstract