New Oxcarbazepine Solvate(10,11-dihydro-10-oxo-5H-dibenzb,fazepine-5-carboxamide) with Chloroform: Crystallization, Stability, and Crystal Structure Analysis

Key Points

• To investigate the crystallization, stability, and molecular structure of oxcarbazepine solvate with chloroform.
• Grew crystals for single crystal X-ray diffraction analysis
• Developed a reproducible procedure for solvate creation
• Analyzed intermolecular interactions in the crystal structure
• Conducted powder XRD analysis during desolvation
• Identified main types of intermolecular interactions in the molecular packing
• Noted formation of new unstable phases during desolvation
• Observed transformation to thermodynamically stable polymorph I of oxcarbazepine

Abstract