Next-generation multimetal complex induces immunogenic cell death with distinct transcriptomic signatures

Key Points

• The study aims to evaluate the effect of a Pt(IV)–Au(I)-gemcitabine prodrug on inducing immunogenic cell death in cancer cells.
• Developed a Pt(IV)–Au(I)-gemcitabine prodrug
• Evaluated cytotoxicity in cancer cell lines
• Assessed transcriptomic signatures after treatment
• The prodrug shows enhanced cytotoxicity compared to individual components
• Induces distinct transcriptomic changes linked to immunogenic cell death
• Demonstrates improved efficacy in stress-related cellular conditions.

Abstract