Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates.

The Hsp90 and calcineurin inhibitors did not have significant antifungal activity alone. Moreover, they did not show a significant antagonistic effect in combination and even increased the efficacy of antifungals at some concentrations.