Editorial: Chromatin modifications and gene expression: from mechanisms to therapeutic implications in disease

Implications in Disease 14 Gene expression is a complex process controlled by an interplay of different regulatory 15 factors that reach far beyond the simple DNA sequence. Epigenetic mechanisms, chromatin 16 architecture, and regulatory RNA molecules are the key components of the molecular networks that 17 coordinate cellular identity, physiological adaptation, and pathological conditions. Over the past 18 decade, advances in high-throughput sequencing technologies, epigenomic profiling, and 19 computational tools have transformed our understanding of these regulatory processes, revealing 20 intricate molecular interactions that operate across genomic, transcriptomic, and epigenomic levels.