June 8, 2005New England Journal of Medicine1,143 citationsOpen Access
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
View Full Paper
Structured PICO
Does intensive lipid-lowering therapy halt the progression or induce regression of calcific aortic stenosis in patients with this condition?
P
Population
Patients with calcific aortic stenosis
I
Intervention
Intensive lipid-lowering therapy (statin therapy)
O
Outcome
Progression of calcific aortic stenosis or its regressionsurrogate
Intensive lipid-lowering therapy does not appear to halt progression or induce regression of calcific aortic stenosis, though small benefits or reductions in clinical endpoints cannot be excluded.
Limitations
- Cannot exclude a small reduction in the rate of disease progression or a significant reduction in major clinical end points
- Not a long-term, large-scale trial
Abstract
Intensive lipid-lowering therapy does not halt the progression of calcific aortic stenosis or induce its regression. This study cannot exclude a small reduction in the rate of disease progression or a significant reduction in major clinical end points. Long-term, large-scale, randomized, controlled trials are needed to establish the role of statin therapy in patients with calcific aortic stenosis.
Cite This Study
Cowell et al. (2005) studied this question.